Abstract: Mirrizi syndrome is a rare benign disease of biliary tract. With the continuous emergence of new concepts and technologies in the field of disease diagnosis and treatment, the standardization of diagnosis and treatment for biliary diseases is also updated. Mirrizi syndrome is difficult to be diagnosed pre-operatively,and intraoperative unclear Calot′s triangle and tissue adhesion caused by gallbladder inflammation and gallbladder fistula formation increase the risk of biliary tract injury, which lead certain challenges for its surgical treatment. Therefore, strict preoperative evaluation and selection of corresponding surgical procedure for different classification of Mirrizi syndrome are of great significance for reducing postoperative complications. In addition, the development of laparoscopic technology reduces the surgical trauma and enhances recovery, but puts forward higher requirements for the experience and operation of surgeons. It is important that reasonably select laparoscopic surgery indications, correctly hold indications of bilioenetric anastomosis, and prevent iatrogenic injury of bile duct on the premise of clearing stones, which is the basic strategy for surgical treatment of Mirrizi syndrome. Based on relevant literatures and clinical practice,the author investigate the therapeutic principles and strategies of Mirrizi syndrome.